Designing Miniprotein Medicine: Efficient, Constraint-Aware Pipelines for De Novo Miniprotein Design

• De novo design models, trained on natural protein distributions, exhibit recurring failure modes such as poor designability when applied unconstrained to miniproteins
• We introduce a constraint-aware pipeline that filters and steers generation to mitigate these failure modes while preserving sequence diversity and designability

Speakers:

Ben Meinen

Head, Protein Design & Investigator

AI Proteins