Alex Nisthal
Director, Protein Engineering Xencor
Alex Nisthal is Director of Protein Engineering at Xencor. His work focuses on the engineering and optimization of therapeutic proteins and antibodies for autoimmune and oncology indications. Throughout his career, he has contributed to multiple biologics research programs through target identification and validation, protein engineering, and candidate selection. Alex earned his PhD from Caltech, BS from Cal Poly Pomona, and continues to pursue innovations at the intersection of protein engineering, bioinformatics, and drug discovery.
Seminars
Thursday 12th November 2026
Target Selection & Selectivity Engineering in a 2+1 T-Cell Engager Format Can Drive Positive Clinical Outcomes
9:10 am
- How do target properties, affinity, and format interplay during early research?
- What molecular properties can lead to successful T-cell engager platforms at multiple levels of development?
- What opportunities are available upon initial positive clinical signals?
