Panel Discussion: Applying Structural Biology Insights to Improve Functional Prediction & Translational Success in Protein Design

• Assessing the limitations of structure prediction methods such as AlphaFold and exploring how moving beyond static models to dynamic systems can improve protein design outcomes
• Examining how cryo-EM data and co-folding models can be combined to enhance prediction of multi-component interactions in complex biologics
• Understanding what drives the gap between structural accuracy and functional performance, and how to better translate in silico designs into biological activity

Speakers:

Ye Che

Senior Director, Global Head of Protein Structure & Biochemistry

GSK

Karen Conrad

Scientific Associate Director, Protein Science, Structural Biology

Takeda